Introduction Enclomiphene is a selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene citrate. Clomiphene is a mixture of ~62% enclomiphene and 38% zuclomiphene; enclomiphene is more anti-estrogenic, whereas zuclomiphene has partial estrogen …

Introduction Pramipexole, a dopamine D2/D3 receptor agonist initially developed for Parkinson’s disease and restless legs syndrome, has shown emerging utility as an off-label treatment for bipolar depression. Its mechanism—preferential D3 stimulation—targets motivational and reward …