Literature Reviews

Here you’ll find in-depth, clinically focused reviews of off-label treatments for psychiatric and neurologic conditions. Each review is structured around data. 

We analyze published trials, dosing patterns, risk profiles, and clinical use cases for medications used beyond their FDA-approved indications. Distilled utility for clinicians, researchers, and patients navigating real-world complexity.

Each review includes:

• Peer-reviewed study citations
• Dosing ranges from real trials
• Side effect/switch risk data
• Clinical positioning (first-line? adjunct? salvage?)
• Cautions and caveats

Browse by Clinical Target:

• Bipolar Depression
• Motivation & Energy
• Unipolar/TRD
• Hormonal / Endocrine
• Anxiety / GAD / Panic
• Sleep / Circadian
• Cognitive Function
• Neuroprotection / Mitochondrial
• Metabolic / Appetite / Weight
• Addiction / Impulse Control
• Psychosis / Schizoaffective
• Somatic Symptoms / Chronic Pain